High-fat breakfast with morning dose Delays Tmax +2hr, Cmax −21% (Yao et al. 2016)
High-protein meal near any dose BBB amino acid competition → ~20% CNS reduction
Poor sleep / high stress Raises effective thresholds ~120 ng/mL
PK profile
24-Hour LD Plasma Concentration — chained from actual log (48h lookback)
Peak LD
—
ng/mL
Min Trough
—
ng/mL
Time <810
—
hrs/day
Time >2800
—
hrs/day
Scheduled Rytary
Rescue doses
Therapeutic ≥810
Dysk EC50 600
High risk ≥2800
Confirmed dose
Projected dose
PK model: Bateman 1-compartment. Rytary tri-phasic ka (IR=3.2, ER1=0.55, ER2=0.18 hr⁻¹, fractions 27/48/25%). PD correction +38% Cmax (FDA NDA 203312). Food effect: Yao et al. 2016. Chained across actual 48h prior log (not steady-state repeat) — missing prior days assume standard schedule at scheduled times, flagged above when used. Unconfirmed doses on displayed day shown at default times/compositions. Semi-quantitative — not a substitute for clinical judgment. Intrasubject variability ±20%.